Assay Detail
Binding
CHEMBL4349201
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Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins by horse-radish peroxidase-coupled amplex red reagent-based fluorescence spectrophotometric method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.93 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 8.08 |
| CHEMBL4554567 | — | — | 1 | 5.44 |
| CHEMBL4537471 | — | — | 1 | 5.33 |
| CHEMBL4439360 | — | — | 1 | 4.85 |
| CHEMBL4463853 | — | — | 1 | 4.74 |
| CHEMBL4571403 | — | — | 1 | 4.70 |
| CHEMBL4466943 | — | — | 1 | 4.68 |
| CHEMBL4474002 | — | — | 1 | 4.44 |
| CHEMBL4525381 | — | — | 1 | 4.39 |
| CHEMBL4550005 | — | — | 1 | 4.36 |
| CHEMBL4466838 | — | — | 1 | 4.15 |
| CHEMBL4543997 | — | — | 1 | 4.03 |
| CHEMBL4541683 | — | — | 1 | - |
| CHEMBL4475218 | — | — | 1 | - |
| CHEMBL4438112 | — | — | 1 | - |
| CHEMBL4546398 | — | — | 1 | - |
| CHEMBL4463260 | — | — | 1 | - |
| CHEMBL4467621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4554567 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL4537471 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL4439360 | — | IC50 | = | 14080.0 | nM | 4.85 |
| CHEMBL4463853 | — | IC50 | = | 18110.0 | nM | 4.74 |
| CHEMBL4571403 | — | IC50 | = | 20120.0 | nM | 4.70 |
| CHEMBL4466943 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4474002 | — | IC50 | = | 35980.0 | nM | 4.44 |
| CHEMBL4525381 | — | IC50 | = | 41110.0 | nM | 4.39 |
| CHEMBL4550005 | — | IC50 | = | 43670.0 | nM | 4.36 |
| CHEMBL4466838 | — | IC50 | = | 71380.0 | nM | 4.15 |
| CHEMBL4543997 | — | IC50 | = | 94020.0 | nM | 4.03 |
| CHEMBL4541683 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4475218 | — | IC50 | = | 151100.0 | nM | - |
| CHEMBL4438112 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4546398 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4463260 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4467621 | — | IC50 | = | 119300.0 | nM | - |