Assay Detail
Functional
CHEMBL4349440
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Growth inhibition of human KM12 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting tropomyosin receptor kinase for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.22 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989939 | LAROTRECTINIB SULFATE | 4.0 | 1 | 8.72 |
| CHEMBL4589373 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989939 | LAROTRECTINIB SULFATE | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4589373 | — | IC50 | = | 19.0 | nM | 7.72 |