Assay Detail
Binding
CHEMBL4349442
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Inhibition of TRK (unknown origin)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting tropomyosin receptor kinase for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.18 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989939 | LAROTRECTINIB SULFATE | 4.0 | 1 | 8.70 |
| CHEMBL4436198 | — | — | 1 | 8.30 |
| CHEMBL457608 | — | — | 1 | 8.10 |
| CHEMBL457393 | — | — | 1 | 8.00 |
| CHEMBL4444276 | — | — | 1 | 7.23 |
| CHEMBL3686124 | — | — | 1 | 7.20 |
| CHEMBL456986 | — | — | 1 | 7.17 |
| CHEMBL4513841 | — | — | 1 | 7.06 |
| CHEMBL3686122 | — | — | 1 | 6.96 |
| CHEMBL4450111 | — | — | 1 | 6.37 |
| CHEMBL3686123 | — | — | 1 | 6.21 |
| CHEMBL4471757 | — | — | 1 | 6.07 |
| CHEMBL4546320 | — | — | 1 | 5.91 |
| CHEMBL4587619 | — | — | 1 | - |
| CHEMBL1289115 | — | — | 1 | - |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989939 | LAROTRECTINIB SULFATE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4436198 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL457608 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL457393 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4444276 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3686124 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL456986 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4513841 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3686122 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4450111 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL3686123 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL4471757 | — | IC50 | = | 859.0 | nM | 6.07 |
| CHEMBL4546320 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4587619 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1289115 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4297627 | SELITRECTINIB | IC50 | > | 1000.0 | nM | - |