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Assay Detail

CHEMBL4349872

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DGAT-mediated oleic acid-induced [14C]neutral lipid synthesis in CHOK1 cells after 6 hrs using [14C]oleic acid by Oil Red O staining-based microscopic analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cricetulus griseus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of neutral lipid synthesis by avarols from a marine sponge.
Ohshiro T, Kobayashi K, Suzuki A, Yamazaki H, Uchida R, Namikoshi M, Tomoda H.
Bioorg Med Chem Lett (2019) 29 : 2283 -2285
PubMed 31253530 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.82 5.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL459814 AVAROL 1 5.17
CHEMBL3971802 1 4.87
CHEMBL3965313 1 4.85
CHEMBL3926518 1 4.63
CHEMBL464646 1 4.56
CHEMBL521017 1 -
CHEMBL3893783 1 -
CHEMBL3919081 1 -
CHEMBL516014 1 -
CHEMBL3892140 1 -
CHEMBL3913531 1 -
CHEMBL3973897 1 -
CHEMBL3893989 1 -
CHEMBL3962935 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL459814 AVAROL IC50 = 6800.0 nM 5.17
CHEMBL3971802 IC50 = 13500.0 nM 4.87
CHEMBL3965313 IC50 = 14200.0 nM 4.85
CHEMBL3926518 IC50 = 23500.0 nM 4.63
CHEMBL464646 IC50 = 27500.0 nM 4.56
CHEMBL521017 IC50 > 27300.0 nM -
CHEMBL3893783 IC50 > 27300.0 nM -
CHEMBL3919081 IC50 > 27300.0 nM -
CHEMBL516014 IC50 > 27300.0 nM -
CHEMBL3892140 IC50 > 31100.0 nM -
CHEMBL3913531 IC50 > 29600.0 nM -
CHEMBL3973897 IC50 > 24400.0 nM -
CHEMBL3893989 IC50 > 29600.0 nM -
CHEMBL3962935 IC50 > 22800.0 nM -