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Assay Detail

CHEMBL4350034

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Functional
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-proliferative activity and structure-activity relationship of honokiol derivatives.
Lin D, Yan Z, Chen A, Ye J, Hu A, Liu J, Peng J, Wu X.
Bioorg Med Chem (2019) 27 : 3729 -3734
PubMed 31278004 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.37 4.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4529304 1 4.78
CHEMBL4585637 1 4.59
CHEMBL4457237 1 4.53
CHEMBL4452386 1 4.53
CHEMBL330227 1 4.52
CHEMBL16901 HONOKIOL 1 4.45
CHEMBL4455452 1 4.43
CHEMBL4513457 1 4.22
CHEMBL4453929 1 4.21
CHEMBL4446582 1 4.14
CHEMBL4176958 1 4.04
CHEMBL4548882 1 4.02
CHEMBL4476833 1 -
CHEMBL4541069 1 -
CHEMBL4458112 1 -
CHEMBL4590159 1 -
CHEMBL4520661 1 -
CHEMBL4474358 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4529304 IC50 = 16570.0 nM 4.78
CHEMBL4585637 IC50 = 25710.0 nM 4.59
CHEMBL4457237 IC50 = 29230.0 nM 4.53
CHEMBL4452386 IC50 = 29320.0 nM 4.53
CHEMBL330227 IC50 = 30350.0 nM 4.52
CHEMBL16901 HONOKIOL IC50 = 35410.0 nM 4.45
CHEMBL4455452 IC50 = 37000.0 nM 4.43
CHEMBL4513457 IC50 = 60800.0 nM 4.22
CHEMBL4453929 IC50 = 61930.0 nM 4.21
CHEMBL4446582 IC50 = 71550.0 nM 4.14
CHEMBL4176958 IC50 = 90370.0 nM 4.04
CHEMBL4548882 IC50 = 96110.0 nM 4.02
CHEMBL4476833 IC50 > 128000.0 nM -
CHEMBL4541069 IC50 > 128000.0 nM -
CHEMBL4458112 IC50 > 128000.0 nM -
CHEMBL4590159 IC50 > 128000.0 nM -
CHEMBL4520661 IC50 > 128000.0 nM -
CHEMBL4474358 IC50 = 115500.0 nM -