Assay Detail
Functional
CHEMBL4350280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NAMALWA cells assessed as reduction in cell viability after 5 days by WST-8 assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NAMALVA |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 10.59 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444762 | — | — | 1 | 11.00 |
| CHEMBL4464612 | — | — | 1 | 11.00 |
| CHEMBL4472761 | — | — | 1 | 11.00 |
| CHEMBL4464871 | — | — | 1 | 10.70 |
| CHEMBL4569759 | — | — | 1 | 10.70 |
| CHEMBL4475215 | — | — | 1 | 10.52 |
| CHEMBL4531187 | — | — | 1 | 10.52 |
| CHEMBL4584305 | — | — | 1 | 10.52 |
| CHEMBL4565413 | — | — | 1 | 10.52 |
| CHEMBL4437662 | — | — | 1 | 10.52 |
| CHEMBL4443670 | — | — | 1 | 10.22 |
| CHEMBL4535956 | — | — | 1 | 10.22 |
| CHEMBL4577159 | — | — | 1 | 10.22 |
| CHEMBL4455015 | — | — | 1 | - |
| CHEMBL4471189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444762 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4464612 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4472761 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4464871 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4569759 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4475215 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4531187 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4584305 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4565413 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4437662 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4443670 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4535956 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4577159 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4455015 | — | IC50 | = | 0.002 | nM | - |
| CHEMBL4471189 | — | IC50 | = | 0.001 | nM | - |