Assay Detail
Binding
CHEMBL4350355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat recombinant FLAG-tagged PTGES expressed in baculovirus infected Hi-5 insect cells using prostaglandin H2 as substrate incubated for 20 mins followed by substrate addition and incubated for 60 sec by TR-FRET assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.84 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459950 | — | — | 1 | 6.79 |
| CHEMBL4435689 | — | — | 1 | 6.72 |
| CHEMBL4443717 | — | — | 1 | 6.05 |
| CHEMBL4526207 | — | — | 1 | 5.90 |
| CHEMBL4439662 | — | — | 1 | 5.87 |
| CHEMBL4467934 | — | — | 1 | 5.59 |
| CHEMBL4456039 | — | — | 1 | 5.07 |
| CHEMBL4537349 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459950 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4435689 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4443717 | — | IC50 | = | 895.0 | nM | 6.05 |
| CHEMBL4526207 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4439662 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4467934 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4456039 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL4537349 | — | IC50 | = | 17700.0 | nM | 4.75 |