Assay Detail
Binding
CHEMBL4350356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse recombinant FLAG-tagged PTGES expressed in baculovirus infected Hi-5 insect cells using prostaglandin H2 as substrate incubated for 20 mins followed by substrate addition and incubated for 60 sec by TR-FRET assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.20 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459950 | — | — | 1 | 7.08 |
| CHEMBL4524932 | — | — | 1 | 6.72 |
| CHEMBL4435689 | — | — | 1 | 6.69 |
| CHEMBL4443717 | — | — | 1 | 6.47 |
| CHEMBL4439662 | — | — | 1 | 6.23 |
| CHEMBL4526207 | — | — | 1 | 6.12 |
| CHEMBL4467934 | — | — | 1 | 6.09 |
| CHEMBL4456039 | — | — | 1 | 5.51 |
| CHEMBL4537349 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459950 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4524932 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4435689 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL4443717 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL4439662 | — | IC50 | = | 584.0 | nM | 6.23 |
| CHEMBL4526207 | — | IC50 | = | 765.0 | nM | 6.12 |
| CHEMBL4467934 | — | IC50 | = | 818.0 | nM | 6.09 |
| CHEMBL4456039 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL4537349 | — | IC50 | = | 12600.0 | nM | 4.90 |