Assay Detail
Binding
CHEMBL4350374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at Km concentration by ADP-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 2 (CHEMBL4204) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione derivatives as Mnk inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.29 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439094 | — | — | 1 | 8.52 |
| CHEMBL4073443 | TOMIVOSERTIB | 2.0 | 1 | 8.52 |
| CHEMBL4466664 | — | — | 1 | 7.37 |
| CHEMBL4449736 | — | — | 1 | 7.09 |
| CHEMBL4535537 | — | — | 1 | 6.36 |
| CHEMBL4454334 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439094 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4073443 | TOMIVOSERTIB | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4466664 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL4449736 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL4535537 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL4454334 | — | Ki | = | 1277.0 | nM | 5.89 |