Assay Detail
Functional
CHEMBL4350831
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Antiproliferative activity against patient-derived GBM cells assessed as cell viability after 48 hrs by 5-Ethynyl-2'-deoxyuridine incorporation assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GBM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis of a novel Crizotinib heptamethine cyanine dye conjugate that potentiates the cytostatic and cytotoxic effects of Crizotinib in patient-derived glioblastoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.11 | 7.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450495 | — | — | 1 | 7.30 |
| CHEMBL4218804 | — | — | 1 | 5.78 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.25 |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450495 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4218804 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL601719 | CRIZOTINIB | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL810 | TEMOZOLOMIDE | Activity | - | — | - |