Assay Detail
Functional
CHEMBL4350835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against patient-derived GBM cells assessed as reduction in cell viability after 48 hrs by 5-Ethynyl-2'-deoxyuridine incorporation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GBM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis of a novel Crizotinib heptamethine cyanine dye conjugate that potentiates the cytostatic and cytotoxic effects of Crizotinib in patient-derived glioblastoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.05 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450495 | — | — | 1 | 8.33 |
| CHEMBL4218804 | — | — | 1 | 6.55 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450495 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4218804 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 540.0 | nM | 6.27 |