Assay Detail
Binding
CHEMBL4351078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.44 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4516283 | — | — | 1 | 8.24 |
| CHEMBL4297584 | TENALISIB | 2.0 | 1 | 7.48 |
| CHEMBL4530831 | — | — | 1 | 7.38 |
| CHEMBL4470131 | — | — | 1 | 7.06 |
| CHEMBL4463183 | — | — | 1 | 7.05 |
| CHEMBL4444179 | — | — | 1 | - |
| CHEMBL4543628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4516283 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4297584 | TENALISIB | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4530831 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4470131 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4463183 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4444179 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL4543628 | — | IC50 | > | 1000.0 | nM | - |