Assay Detail

CHEMBL4351115

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ADMET

Cytotoxicity against in human Neutrophil cells

ChEMBL ↗

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Target

Neutrophil (CHEMBL5314326) ↗

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Primary target Neutrophil

CHEMBL5314326

Anchored from Assay target.

Protein identity Neutrophil

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	Neutrophil
Confidence	1 — Organism
Curated By	Autocuration

Target

Neutrophil (CHEMBL5314326) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.

Perry MWD, Abdulai R, Mogemark M, Petersen J, Thomas MJ, Valastro B, Westin Eriksson A.
J Med Chem (2019) 62 : 4783 -4814
PubMed 30582813 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.80	7.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4297648	SELETALISIB	2.0	1	7.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4297648	SELETALISIB	IC50	=	16.0	nM	7.80