Assay Detail
Binding
CHEMBL4351122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged PI3Kgamma in human U937 cells using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 mins by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.58 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3919512 | — | — | 1 | 7.60 |
| CHEMBL3934989 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3919512 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3934989 | — | IC50 | = | 28.0 | nM | 7.55 |