Assay Detail
Binding
CHEMBL4351153
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Binding affinity to XIAP-BIR3 domain (241 to 356 residues) (unknown origin) by fluorescence polarization-based competition assay
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.51 | 8.30 |
| IC50 | 1 | 7.78 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460352 | — | — | 1 | 8.30 |
| CHEMBL2096803 | — | — | 1 | 7.92 |
| CHEMBL4459769 | — | — | 1 | 7.80 |
| CHEMBL1230673 | — | — | 1 | 7.80 |
| CHEMBL4452928 | — | — | 1 | 7.78 |
| CHEMBL2063869 | GDC-0152 | 1.0 | 1 | 7.55 |
| CHEMBL189768 | — | — | 1 | 7.54 |
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.28 |
| CHEMBL4518625 | — | — | 1 | 6.70 |
| CHEMBL4460096 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460352 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL2096803 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4459769 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL1230673 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL4452928 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL2063869 | GDC-0152 | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL189768 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL2431768 | LCL-161 | Kd | = | 52.7 | nM | 7.28 |
| CHEMBL4518625 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL4460096 | — | Kd | = | 220.0 | nM | 6.66 |