Assay Detail
Binding
CHEMBL4351162
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Binding affinity to cIAP2-BIR3 domain (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 3 (CHEMBL5335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.04 | 7.89 |
| IC50 | 2 | 7.07 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.89 |
| CHEMBL3108931 | — | — | 1 | 7.68 |
| CHEMBL3039522 | BIRINAPANT | 2.0 | 1 | 7.44 |
| CHEMBL2063869 | GDC-0152 | 1.0 | 1 | 7.37 |
| CHEMBL4452928 | — | — | 1 | 6.45 |
| CHEMBL1230673 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | Kd | = | 12.9 | nM | 7.89 |
| CHEMBL3108931 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3039522 | BIRINAPANT | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL2063869 | GDC-0152 | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL4452928 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL1230673 | — | Kd | = | 3400.0 | nM | 5.47 |