Assay Detail
Binding
CHEMBL4351338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant rat GluN1a/GluN2D expressed in Xenopus laevis oocytes at -40 mV holding potential in presence of glutamate by two-electrode voltage clamp electrophysiology method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Ionotropic glutamate receptor NMDA 1/2D (CHEMBL3038506) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 4.46 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444367 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444367 | — | EC50 | = | 35000.0 | nM | 4.46 |