Assay Detail
Binding
CHEMBL4351504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-flumazenil from human GABAA alpha2beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Identification of a Novel, Functionally Subtype Selective GABA<sub>A</sub> Positive Allosteric Modulator (PF-06372865).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.36 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3647536 | DARIGABAT | 2.0 | 1 | 8.54 |
| CHEMBL4545044 | — | — | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3647536 | DARIGABAT | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL4545044 | — | Ki | = | 6.6 | nM | 8.18 |