Assay Detail
Binding
CHEMBL4351519
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Displacement of [3H]-flumazenil from rat GABAA alpha1beta3gamma2 receptor expressed in CHO cell membranes measured after 2 hrs by liquid scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Identification of a Novel, Functionally Subtype Selective GABA<sub>A</sub> Positive Allosteric Modulator (PF-06372865).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.39 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3647536 | DARIGABAT | 2.0 | 1 | 9.47 |
| CHEMBL4545044 | — | — | 1 | 9.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3647536 | DARIGABAT | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL4545044 | — | Ki | = | 0.5 | nM | 9.30 |