Assay Detail
Functional
CHEMBL4352147
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Antiproliferative activity against cisplatin-resistant human A2780/CP70 cells measured after 96 hrs by MTT assay
30
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Expanding the Chemical Space of Withaferin A by Incorporating Silicon To Improve Its Clinical Potential on Human Ovarian Carcinoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.59 | 8.44 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4449819 | — | — | 1 | 8.44 |
| CHEMBL4437607 | — | — | 1 | 7.89 |
| CHEMBL4437317 | — | — | 1 | 7.72 |
| CHEMBL4516436 | — | — | 1 | 7.70 |
| CHEMBL4439606 | — | — | 1 | 7.68 |
| CHEMBL4530865 | — | — | 1 | 7.66 |
| CHEMBL4575625 | — | — | 1 | 7.64 |
| CHEMBL4435676 | — | — | 1 | 7.60 |
| CHEMBL4441807 | — | — | 1 | 7.56 |
| CHEMBL4455055 | — | — | 1 | 7.55 |
| CHEMBL4571619 | — | — | 1 | 7.54 |
| CHEMBL4529311 | — | — | 1 | 7.54 |
| CHEMBL4471566 | — | — | 1 | 7.51 |
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 7.50 |
| CHEMBL4453913 | — | — | 1 | 7.48 |
| CHEMBL4448830 | — | — | 1 | 7.47 |
| CHEMBL4587655 | — | — | 1 | 7.46 |
| CHEMBL4554599 | — | — | 1 | 7.46 |
| CHEMBL4588567 | — | — | 1 | 7.21 |
| CHEMBL4462031 | — | — | 1 | 7.16 |
| CHEMBL4465868 | — | — | 1 | - |
| CHEMBL4464240 | — | — | 1 | - |
| CHEMBL4455119 | — | — | 1 | - |
| CHEMBL4551571 | — | — | 1 | - |
| CHEMBL4562925 | — | — | 1 | - |
| CHEMBL4443535 | — | — | 1 | - |
| CHEMBL4533241 | — | — | 1 | - |
| CHEMBL2047415 | — | — | 1 | - |
| CHEMBL2047419 | — | — | 1 | - |
| CHEMBL2047418 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4449819 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4437607 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL4437317 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4516436 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4439606 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4530865 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4575625 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4435676 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL4441807 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL4455055 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL4571619 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4529311 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4471566 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL517080 | WITHAFERIN A | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4453913 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4448830 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4587655 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4554599 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4588567 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4462031 | — | IC50 | = | 68.8 | nM | 7.16 |
| CHEMBL4465868 | — | Activity | - | — | - | |
| CHEMBL4464240 | — | Activity | - | — | - | |
| CHEMBL4455119 | — | Activity | - | — | - | |
| CHEMBL4551571 | — | Activity | - | — | - | |
| CHEMBL4562925 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4443535 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL4533241 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2047415 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL2047419 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2047418 | — | IC50 | > | 100.0 | nM | - |