Assay Detail
ADMET
CHEMBL4352148
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Cytotoxicity against human ARPE19 cells measured after 96 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | ARPE-19 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Expanding the Chemical Space of Withaferin A by Incorporating Silicon To Improve Its Clinical Potential on Human Ovarian Carcinoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.62 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047418 | — | — | 1 | 7.91 |
| CHEMBL4437607 | — | — | 1 | 7.52 |
| CHEMBL4449819 | — | — | 1 | 7.52 |
| CHEMBL2047415 | — | — | 1 | 7.50 |
| CHEMBL4453913 | — | — | 1 | 7.50 |
| CHEMBL4554599 | — | — | 1 | 7.43 |
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 7.43 |
| CHEMBL4437317 | — | — | 1 | 7.28 |
| CHEMBL4588567 | — | — | 1 | 7.21 |
| CHEMBL4455055 | — | — | 1 | 7.16 |
| CHEMBL4471566 | — | — | 1 | 7.07 |
| CHEMBL4441807 | — | — | 1 | 7.04 |
| CHEMBL4530865 | — | — | 1 | 6.58 |
| CHEMBL4529311 | — | — | 1 | 6.51 |
| CHEMBL4575625 | — | — | 1 | 6.51 |
| CHEMBL4435676 | — | — | 1 | 6.50 |
| CHEMBL4533241 | — | — | 1 | 6.21 |
| CHEMBL4462031 | — | — | 1 | 6.09 |
| CHEMBL2047419 | — | — | 1 | 5.78 |
| CHEMBL4439606 | — | — | 1 | 5.76 |
| CHEMBL4516436 | — | — | 1 | 5.73 |
| CHEMBL4562925 | — | — | 1 | 5.69 |
| CHEMBL4448830 | — | — | 1 | 5.67 |
| CHEMBL4443535 | — | — | 1 | 5.64 |
| CHEMBL4571619 | — | — | 1 | 5.64 |
| CHEMBL4587655 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047418 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL4437607 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4449819 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2047415 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4453913 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4554599 | — | IC50 | = | 37.5 | nM | 7.43 |
| CHEMBL517080 | WITHAFERIN A | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4437317 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4588567 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4455055 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4471566 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4441807 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4530865 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4529311 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4575625 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4435676 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL4533241 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL4462031 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL2047419 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4439606 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4516436 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL4562925 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4448830 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL4443535 | — | IC50 | = | 2305.0 | nM | 5.64 |
| CHEMBL4571619 | — | IC50 | = | 2295.0 | nM | 5.64 |
| CHEMBL4587655 | — | IC50 | = | 6500.0 | nM | 5.19 |