Assay Detail
Binding
CHEMBL4352646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in antihuman IgM-stimulated AKT phosphorylation at Ser473 residue preincubated for 60 mins followed by antihuman IgM stimulation and measured after 15 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ramos |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.36 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548876 | — | — | 1 | 9.00 |
| CHEMBL3039502 | DUVELISIB | 4.0 | 1 | 9.00 |
| CHEMBL4549473 | — | — | 1 | 8.52 |
| CHEMBL4522342 | — | — | 1 | 8.52 |
| CHEMBL4574883 | — | — | 1 | 8.52 |
| CHEMBL4530831 | — | — | 1 | 8.52 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.40 |
| CHEMBL4463472 | — | — | 1 | 8.30 |
| CHEMBL4467526 | — | — | 1 | 7.80 |
| CHEMBL4445566 | — | — | 1 | 7.68 |
| CHEMBL4468887 | — | — | 1 | 7.68 |
| CHEMBL4471912 | — | — | 1 | - |
| CHEMBL4446047 | — | — | 1 | - |
| CHEMBL4520300 | — | — | 1 | - |
| CHEMBL4443601 | — | — | 1 | - |
| CHEMBL4446644 | — | — | 1 | - |
| CHEMBL4514752 | — | — | 1 | - |
| CHEMBL4442420 | — | — | 1 | - |
| CHEMBL4438693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548876 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3039502 | DUVELISIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4549473 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4522342 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4574883 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4530831 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4463472 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4467526 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4445566 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4468887 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4471912 | — | IC50 | - | — | - | |
| CHEMBL4446047 | — | IC50 | - | — | - | |
| CHEMBL4520300 | — | IC50 | - | — | - | |
| CHEMBL4443601 | — | IC50 | - | — | - | |
| CHEMBL4446644 | — | IC50 | - | — | - | |
| CHEMBL4514752 | — | IC50 | - | — | - | |
| CHEMBL4442420 | — | IC50 | - | — | - | |
| CHEMBL4438693 | — | IC50 | - | — | - |