Assay Detail
Functional
CHEMBL4352730
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Antimalarial activity against synchronized ring stage CQ-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439637 | — | — | 1 | 9.00 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.40 |
| CHEMBL4442854 | — | — | 1 | 8.30 |
| CHEMBL4442674 | — | — | 1 | 8.05 |
| CHEMBL4472824 | — | — | 1 | 7.85 |
| CHEMBL4564002 | — | — | 1 | 7.62 |
| CHEMBL4467013 | — | — | 1 | 7.58 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.50 |
| CHEMBL4434685 | — | — | 1 | 7.38 |
| CHEMBL4437416 | — | — | 1 | 7.14 |
| CHEMBL4456644 | — | — | 1 | 7.12 |
| CHEMBL4516951 | — | — | 1 | 7.08 |
| CHEMBL4555968 | — | — | 1 | 6.79 |
| CHEMBL4527228 | — | — | 1 | 6.69 |
| CHEMBL4475837 | — | — | 1 | 6.64 |
| CHEMBL4594166 | — | — | 1 | 5.90 |
| CHEMBL4473513 | — | — | 1 | 5.59 |
| CHEMBL4555310 | — | — | 1 | 5.16 |
| CHEMBL4562998 | — | — | 1 | - |
| CHEMBL1458713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439637 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4442854 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4442674 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4472824 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4564002 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4467013 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4434685 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4437416 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4456644 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4516951 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4555968 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4527228 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL4475837 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL4594166 | — | IC50 | = | 1248.0 | nM | 5.90 |
| CHEMBL4473513 | — | IC50 | = | 2593.0 | nM | 5.59 |
| CHEMBL4555310 | — | IC50 | = | 6994.0 | nM | 5.16 |
| CHEMBL4562998 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1458713 | — | IC50 | - | — | - |