Assay Detail
Functional
CHEMBL4352731
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Antimalarial activity against synchronized ring stage CQ-resistant Plasmodium falciparum W2 infected in human erythrocytes incubated for 24 hrs followed by compound washout and subsequent compound addition and measured after 48 hrs by YOYO-1 probe-based flow cytometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.23 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439637 | — | — | 1 | 8.40 |
| CHEMBL4442854 | — | — | 1 | 8.15 |
| CHEMBL4564002 | — | — | 1 | 8.00 |
| CHEMBL4442674 | — | — | 1 | 8.00 |
| CHEMBL4472824 | — | — | 1 | 7.96 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.68 |
| CHEMBL4467013 | — | — | 1 | 7.55 |
| CHEMBL4437416 | — | — | 1 | 7.43 |
| CHEMBL4434685 | — | — | 1 | 7.31 |
| CHEMBL4456644 | — | — | 1 | 7.27 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.26 |
| CHEMBL4555968 | — | — | 1 | 7.26 |
| CHEMBL4527228 | — | — | 1 | 7.23 |
| CHEMBL4516951 | — | — | 1 | 7.02 |
| CHEMBL4475837 | — | — | 1 | 6.92 |
| CHEMBL4594166 | — | — | 1 | 6.32 |
| CHEMBL4473513 | — | — | 1 | 6.16 |
| CHEMBL4555310 | — | — | 1 | 5.99 |
| CHEMBL4562998 | — | — | 1 | 5.43 |
| CHEMBL1458713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439637 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4442854 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4564002 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4442674 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4472824 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4467013 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4437416 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4434685 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4456644 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4555968 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4527228 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4516951 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4475837 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4594166 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL4473513 | — | IC50 | = | 691.0 | nM | 6.16 |
| CHEMBL4555310 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL4562998 | — | IC50 | = | 3729.0 | nM | 5.43 |
| CHEMBL1458713 | — | IC50 | - | — | - |