Assay Detail
Binding
CHEMBL4352750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by microbeta liquid scintillation counting analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.74 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444602 | — | — | 1 | 9.85 |
| CHEMBL3989870 | BERZOSERTIB | 2.0 | 1 | 9.78 |
| CHEMBL4533440 | — | — | 1 | 9.68 |
| CHEMBL4443525 | — | — | 1 | 9.57 |
| CHEMBL4566104 | — | — | 1 | 9.28 |
| CHEMBL4448538 | — | — | 1 | 9.12 |
| CHEMBL4434665 | — | — | 1 | 9.00 |
| CHEMBL4440048 | — | — | 1 | 9.00 |
| CHEMBL4467820 | — | — | 1 | 9.00 |
| CHEMBL4467848 | — | — | 1 | 8.91 |
| CHEMBL4530813 | — | — | 1 | 8.70 |
| CHEMBL4541587 | — | — | 1 | 8.62 |
| CHEMBL1766793 | — | — | 1 | 8.40 |
| CHEMBL4558884 | — | — | 1 | 8.40 |
| CHEMBL4445532 | — | — | 1 | 8.30 |
| CHEMBL3695214 | — | — | 1 | 8.22 |
| CHEMBL4473876 | — | — | 1 | 7.68 |
| CHEMBL4593939 | — | — | 1 | 7.58 |
| CHEMBL2409216 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444602 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3989870 | BERZOSERTIB | Ki | = | 0.165 | nM | 9.78 |
| CHEMBL4533440 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL4443525 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL4566104 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL4448538 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL4434665 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4440048 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4467820 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4467848 | — | Ki | = | 1.24 | nM | 8.91 |
| CHEMBL4530813 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4541587 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1766793 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4558884 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4445532 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3695214 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4473876 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4593939 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2409216 | — | Ki | = | 90.0 | nM | 7.05 |