Assay Detail
Binding
CHEMBL4352766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GSK3beta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.75 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4467820 | — | — | 1 | 7.66 |
| CHEMBL3989870 | BERZOSERTIB | 2.0 | 1 | 6.85 |
| CHEMBL4530813 | — | — | 1 | 6.28 |
| CHEMBL4440048 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4467820 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3989870 | BERZOSERTIB | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4530813 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL4440048 | — | Ki | = | 650.0 | nM | 6.19 |