Assay Detail
Binding
CHEMBL4352821
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 peptide as substrate incubated for 1 hr by LanthaScreen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and pharmacological evaluation of a novel mTOR-targeted anti-EV71 agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.41 | 7.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4525212 | — | — | 1 | 7.53 |
| CHEMBL4453652 | — | — | 1 | 6.59 |
| CHEMBL4447016 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4525212 | — | IC50 | = | 29.24 | nM | 7.53 |
| CHEMBL4453652 | — | IC50 | = | 256.8 | nM | 6.59 |
| CHEMBL4447016 | — | IC50 | = | 7766.0 | nM | 5.11 |