Assay Detail
Functional
CHEMBL4352918
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Cytostatic activity against human MDA-MB-231 cells preincubated for 24 hrs under serum free condition followed by compound washout and further incubation for 48 hrs in presence of serum by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sequence modification of heptapeptide selected by phage display as homing device for HT-29 colon cancer cells to improve the anti-tumour activity of drug delivery systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.28 |
| CHEMBL4536320 | — | — | 1 | 5.34 |
| CHEMBL4454011 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 52.9 | nM | 7.28 |
| CHEMBL4536320 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4454011 | — | IC50 | = | 6300.0 | nM | 5.20 |