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Assay Detail

CHEMBL4352921

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytostatic activity against human HT-29 cells preincubated for 24 hrs under serum free condition followed by compound washout and further incubation for 48 hrs in presence of serum by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Sequence modification of heptapeptide selected by phage display as homing device for HT-29 colon cancer cells to improve the anti-tumour activity of drug delivery systems.
Kiss K, Biri-Kovács B, Szabó R, Ranđelović I, Enyedi KN, Schlosser G, Orosz Á, Kapuvári B, Tóvári J, Mező G.
Eur J Med Chem (2019) 176 : 105 -116
PubMed 31100648 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.82 6.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL178 DAUNORUBICIN 4.0 1 6.69
CHEMBL4567566 1 5.50
CHEMBL4475623 1 5.44
CHEMBL4536320 1 5.19
CHEMBL4570885 1 5.12
CHEMBL4434807 1 4.96
CHEMBL4453710 1 4.94
CHEMBL4463266 1 4.81
CHEMBL4568418 1 4.75
CHEMBL4438559 1 4.66
CHEMBL4566663 1 4.62
CHEMBL4456835 1 4.61
CHEMBL4534922 1 4.55
CHEMBL4514281 1 4.53
CHEMBL4454011 1 4.52
CHEMBL4451369 1 4.43
CHEMBL4436380 1 4.42
CHEMBL4582685 1 4.30
CHEMBL4587205 1 4.26
CHEMBL4470273 1 4.15
CHEMBL4455054 1 -
CHEMBL4468958 1 -
CHEMBL4473914 1 -
CHEMBL4435196 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL178 DAUNORUBICIN IC50 = 202.9 nM 6.69
CHEMBL4567566 IC50 = 3200.0 nM 5.50
CHEMBL4475623 IC50 = 3600.0 nM 5.44
CHEMBL4536320 IC50 = 6500.0 nM 5.19
CHEMBL4570885 IC50 = 7500.0 nM 5.12
CHEMBL4434807 IC50 = 10900.0 nM 4.96
CHEMBL4453710 IC50 = 11500.0 nM 4.94
CHEMBL4463266 IC50 = 15400.0 nM 4.81
CHEMBL4568418 IC50 = 17700.0 nM 4.75
CHEMBL4438559 IC50 = 21700.0 nM 4.66
CHEMBL4566663 IC50 = 24100.0 nM 4.62
CHEMBL4456835 IC50 = 24800.0 nM 4.61
CHEMBL4534922 IC50 = 28000.0 nM 4.55
CHEMBL4514281 IC50 = 29500.0 nM 4.53
CHEMBL4454011 IC50 = 30100.0 nM 4.52
CHEMBL4451369 IC50 = 36800.0 nM 4.43
CHEMBL4436380 IC50 = 38400.0 nM 4.42
CHEMBL4582685 IC50 = 50300.0 nM 4.30
CHEMBL4587205 IC50 = 54300.0 nM 4.26
CHEMBL4470273 IC50 = 70900.0 nM 4.15
CHEMBL4455054 IC50 > 50000.0 nM -
CHEMBL4468958 IC50 > 100000.0 nM -
CHEMBL4473914 IC50 > 100000.0 nM -
CHEMBL4435196 IC50 > 100000.0 nM -