Assay Detail
Binding
CHEMBL4353003
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Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDMX (2 to 185 residues) by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.42 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3653158 | — | — | 1 | 6.33 |
| CHEMBL3687226 | — | — | 1 | 5.38 |
| CHEMBL3653220 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3653158 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL3687226 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL3653220 | — | IC50 | = | 27800.0 | nM | 4.56 |