Assay Detail
Binding
CHEMBL4353049
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Inhibition of trypsin (unknown origin) using Boc-Val-Pro-Arg-AMC as substrate preincubated with enzyme for 15 mins followed by addition of substrate by fluorescence plate reader analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.81 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344303 | — | — | 1 | 8.87 |
| CHEMBL4561509 | — | — | 1 | 8.81 |
| CHEMBL4586045 | — | — | 1 | 8.56 |
| CHEMBL590799 | CAMOSTAT | 3.0 | 1 | 8.46 |
| CHEMBL4451902 | — | — | 1 | 7.55 |
| CHEMBL4439506 | — | — | 1 | 5.08 |
| CHEMBL4453926 | — | — | 1 | 5.01 |
| CHEMBL4467388 | — | — | 1 | 4.62 |
| CHEMBL4437757 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344303 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL4561509 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL4586045 | — | IC50 | = | 2.78 | nM | 8.56 |
| CHEMBL590799 | CAMOSTAT | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4451902 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4439506 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL4453926 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL4467388 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4437757 | — | IC50 | = | 46300.0 | nM | 4.33 |