Assay Detail
Binding
CHEMBL4353098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat liver mitochondrial MAOA [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation counting analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Multi-target design strategies for the improved treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.64 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1929421 | — | — | 1 | 8.28 |
| CHEMBL1929418 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1929421 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1929418 | — | IC50 | = | 100.0 | nM | 7.00 |