Assay Detail
Binding
CHEMBL4353357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H] prazosin from human cloned adrenoceptor alpha 1D expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counter
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.85 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4467585 | — | — | 1 | 8.99 |
| CHEMBL4462600 | — | — | 1 | 8.92 |
| CHEMBL4526865 | — | — | 1 | 8.36 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 8.34 |
| CHEMBL4582160 | — | — | 1 | 8.30 |
| CHEMBL4458714 | — | — | 1 | 8.24 |
| CHEMBL4439658 | — | — | 1 | 8.23 |
| CHEMBL4570387 | — | — | 1 | 8.15 |
| CHEMBL286003 | — | — | 1 | 8.03 |
| CHEMBL4468507 | — | — | 1 | 8.00 |
| CHEMBL37883 | — | — | 1 | 7.94 |
| CHEMBL4551941 | — | — | 1 | 7.80 |
| CHEMBL4579802 | — | — | 1 | 7.78 |
| CHEMBL4588223 | — | — | 1 | 7.60 |
| CHEMBL4462768 | — | — | 1 | 7.53 |
| CHEMBL4520390 | — | — | 1 | 7.52 |
| CHEMBL4558985 | — | — | 1 | 7.24 |
| CHEMBL4473623 | — | — | 1 | 7.12 |
| CHEMBL4457585 | — | — | 1 | 7.06 |
| CHEMBL4580335 | — | — | 1 | 7.02 |
| CHEMBL4544457 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4467585 | — | Ki | = | 1.023 | nM | 8.99 |
| CHEMBL4462600 | — | Ki | = | 1.202 | nM | 8.92 |
| CHEMBL4526865 | — | Ki | = | 4.365 | nM | 8.36 |
| CHEMBL31354 | WAY-100,635 | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL4582160 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL4458714 | — | Ki | = | 5.754 | nM | 8.24 |
| CHEMBL4439658 | — | Ki | = | 5.888 | nM | 8.23 |
| CHEMBL4570387 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL286003 | — | Ki | = | 9.333 | nM | 8.03 |
| CHEMBL4468507 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL37883 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL4551941 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL4579802 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL4588223 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL4462768 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL4520390 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL4558985 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL4473623 | — | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL4457585 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL4580335 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL4544457 | — | Ki | = | 177.83 | nM | 6.75 |