Assay Detail
ADMET
CHEMBL4353493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.63 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554455 | — | — | 1 | 6.55 |
| CHEMBL4469292 | — | — | 1 | 6.14 |
| CHEMBL4458861 | — | — | 1 | 5.97 |
| CHEMBL4438250 | — | — | 1 | 5.76 |
| CHEMBL4590434 | — | — | 1 | 5.61 |
| CHEMBL4453262 | — | — | 1 | 5.21 |
| CHEMBL458997 | — | — | 1 | 5.06 |
| CHEMBL3137331 | DEFACTINIB | 3.0 | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554455 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4469292 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4458861 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4438250 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4590434 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL4453262 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL458997 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL3137331 | DEFACTINIB | IC50 | = | 18420.0 | nM | 4.74 |