Assay Detail
Binding
CHEMBL4353634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as reduction in production of H202 using p-tyramine as substrate incubated for 30 mins followed by substrate addition by horse radish peroxidase/Amplex red reagent based fluorescence assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.99 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 6.82 |
| CHEMBL4435127 | — | — | 1 | 5.83 |
| CHEMBL4514270 | — | — | 1 | 5.48 |
| CHEMBL4451426 | — | — | 1 | 5.11 |
| CHEMBL4459207 | — | — | 1 | 5.09 |
| CHEMBL4455144 | — | — | 1 | 4.96 |
| CHEMBL4520073 | — | — | 1 | 4.95 |
| CHEMBL4548899 | — | — | 1 | 4.91 |
| CHEMBL4554961 | — | — | 1 | 4.86 |
| CHEMBL4456862 | — | — | 1 | 4.85 |
| CHEMBL4543829 | — | — | 1 | 4.84 |
| CHEMBL4567714 | — | — | 1 | 4.80 |
| CHEMBL4472217 | — | — | 1 | 4.75 |
| CHEMBL4446207 | — | — | 1 | 4.74 |
| CHEMBL4454141 | — | — | 1 | 4.70 |
| CHEMBL4450296 | — | — | 1 | 4.68 |
| CHEMBL4455630 | — | — | 1 | 4.66 |
| CHEMBL4449439 | — | — | 1 | 4.66 |
| CHEMBL4591817 | — | — | 1 | 4.63 |
| CHEMBL4469654 | — | — | 1 | 4.54 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL673 | PARGYLINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4435127 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4514270 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4451426 | — | IC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL4459207 | — | IC50 | = | 8090.0 | nM | 5.09 |
| CHEMBL4455144 | — | IC50 | = | 10970.0 | nM | 4.96 |
| CHEMBL4520073 | — | IC50 | = | 11130.0 | nM | 4.95 |
| CHEMBL4548899 | — | IC50 | = | 12260.0 | nM | 4.91 |
| CHEMBL4554961 | — | IC50 | = | 13780.0 | nM | 4.86 |
| CHEMBL4456862 | — | IC50 | = | 14010.0 | nM | 4.85 |
| CHEMBL4543829 | — | IC50 | = | 14440.0 | nM | 4.84 |
| CHEMBL4567714 | — | IC50 | = | 15710.0 | nM | 4.80 |
| CHEMBL4472217 | — | IC50 | = | 17690.0 | nM | 4.75 |
| CHEMBL4446207 | — | IC50 | = | 18070.0 | nM | 4.74 |
| CHEMBL4454141 | — | IC50 | = | 20030.0 | nM | 4.70 |
| CHEMBL4450296 | — | IC50 | = | 21080.0 | nM | 4.68 |
| CHEMBL4455630 | — | IC50 | = | 22090.0 | nM | 4.66 |
| CHEMBL4449439 | — | IC50 | = | 22120.0 | nM | 4.66 |
| CHEMBL4591817 | — | IC50 | = | 23440.0 | nM | 4.63 |
| CHEMBL4469654 | — | IC50 | = | 29030.0 | nM | 4.54 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - | |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |