Assay Detail
Binding
CHEMBL4353636
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Inhibition of electric eel AChE assessed as reduction in production of H202 using acetylcholine as substrate incubated for 15 mins followed by substrate addition by horse radish peroxidase/Amplex red reagent based fluorescence assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.45 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.52 |
| CHEMBL4514270 | — | — | 1 | 5.87 |
| CHEMBL4435127 | — | — | 1 | 5.76 |
| CHEMBL4451426 | — | — | 1 | 5.75 |
| CHEMBL4449439 | — | — | 1 | 5.74 |
| CHEMBL4446207 | — | — | 1 | 5.59 |
| CHEMBL4472217 | — | — | 1 | 5.36 |
| CHEMBL4454141 | — | — | 1 | 5.34 |
| CHEMBL4520073 | — | — | 1 | 5.29 |
| CHEMBL4459207 | — | — | 1 | 5.23 |
| CHEMBL4450296 | — | — | 1 | 5.23 |
| CHEMBL4455144 | — | — | 1 | 5.20 |
| CHEMBL4591817 | — | — | 1 | 5.17 |
| CHEMBL4455630 | — | — | 1 | 5.16 |
| CHEMBL4567714 | — | — | 1 | 5.16 |
| CHEMBL4469654 | — | — | 1 | 5.16 |
| CHEMBL4456862 | — | — | 1 | 5.15 |
| CHEMBL4543829 | — | — | 1 | 5.14 |
| CHEMBL4548899 | — | — | 1 | 5.12 |
| CHEMBL4554961 | — | — | 1 | 5.09 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4514270 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4435127 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4451426 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4449439 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4446207 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL4472217 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL4454141 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL4520073 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL4459207 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL4450296 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL4455144 | — | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL4591817 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL4455630 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL4567714 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL4469654 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL4456862 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL4543829 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL4548899 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL4554961 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - | |
| CHEMBL673 | PARGYLINE | IC50 | - | — | - |