Assay Detail
Binding
CHEMBL4353693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM3A (unknown origin) by Alphascreen assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.39 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592908 | — | — | 1 | 5.73 |
| CHEMBL4585876 | — | — | 1 | 5.70 |
| CHEMBL4516101 | — | — | 1 | 5.25 |
| CHEMBL4449500 | — | — | 1 | 5.24 |
| CHEMBL4525269 | — | — | 1 | 5.21 |
| CHEMBL4447515 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592908 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4585876 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL4516101 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL4449500 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL4525269 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL4447515 | — | IC50 | = | 6420.0 | nM | 5.19 |