Assay Detail
Binding
CHEMBL4354288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as decrease in H2O2 production using p-tyramine as substrate incubated for 20 mins by horse-radish peroxidase/amplex red-based fluorescence method
33
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.78 | 9.41 |
| Ki | 13 | 9.27 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319256 | — | — | 2 | 9.77 |
| CHEMBL3319244 | — | — | 2 | 9.59 |
| CHEMBL3319272 | — | — | 2 | 9.57 |
| CHEMBL3319247 | — | — | 2 | 9.54 |
| CHEMBL3317469 | — | — | 2 | 9.52 |
| CHEMBL3319273 | — | — | 2 | 9.34 |
| CHEMBL4104691 | — | — | 2 | 9.32 |
| CHEMBL4539722 | — | — | 3 | 9.24 |
| CHEMBL4466571 | — | — | 3 | 9.24 |
| CHEMBL4567537 | — | — | 3 | 9.08 |
| CHEMBL4449231 | — | — | 3 | 9.03 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 3 | 8.64 |
| CHEMBL3319254 | — | — | 2 | 8.62 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.26 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319256 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL3319244 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL3319272 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL3319247 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL3317469 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3319256 | — | IC50 | = | 0.389 | nM | 9.41 |
| CHEMBL3319273 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL4104691 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL4466571 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL4539722 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL3319244 | — | IC50 | = | 0.5888 | nM | 9.23 |
| CHEMBL3319272 | — | IC50 | = | 0.6166 | nM | 9.21 |
| CHEMBL3319247 | — | IC50 | = | 0.6607 | nM | 9.18 |
| CHEMBL3317469 | — | IC50 | = | 0.6761 | nM | 9.17 |
| CHEMBL4567537 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL4449231 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL3319273 | — | IC50 | = | 1.023 | nM | 8.99 |
| CHEMBL4104691 | — | IC50 | = | 1.072 | nM | 8.97 |
| CHEMBL4539722 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL4466571 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL4466571 | — | IC50 | = | 1.29 | nM | 8.89 |
| CHEMBL4539722 | — | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL4567537 | — | IC50 | = | 1.905 | nM | 8.72 |
| CHEMBL4567537 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL4449231 | — | IC50 | = | 2.089 | nM | 8.68 |
| CHEMBL4449231 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL396778 | SAFINAMIDE | Ki | = | 2.29 | nM | 8.64 |
| CHEMBL3319254 | — | Ki | = | 2.39 | nM | 8.62 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 5.18 | nM | 8.29 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL3319254 | — | IC50 | = | 5.37 | nM | 8.27 |
| CHEMBL972 | SELEGILINE | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL887 | RASAGILINE | IC50 | = | 13.0 | nM | 7.89 |