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Assay Detail

CHEMBL4354739

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human NCI-H460/MX20 cells assessed as inhibition of cell viability incubated for 2 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Benzoyl indoles with metabolic stability as reversal agents for ABCG2-mediated multidrug resistance.
Cai CY, Zhai H, Lei ZN, Tan CP, Chen BL, Du ZY, Wang JQ, Zhang YK, Wang YJ, Gupta P, Wang B, Chen ZS.
Eur J Med Chem (2019) 179 : 849 -862
PubMed 31302589 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.36 5.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL186701 1 5.24
CHEMBL58 MITOXANTRONE 4.0 1 4.39
CHEMBL4531331 1 4.27
CHEMBL4439843 1 4.21
CHEMBL4559126 1 4.17
CHEMBL4454229 1 4.16
CHEMBL4555875 1 4.08
CHEMBL4560344 1 -
CHEMBL188418 1 -
CHEMBL4435996 1 -
CHEMBL4573546 1 -
CHEMBL4455401 1 -
CHEMBL4460545 1 -
CHEMBL4438086 1 -
CHEMBL4591286 1 -
CHEMBL4462998 1 -
CHEMBL4436800 1 -
CHEMBL4552586 1 -
CHEMBL4448720 1 -
CHEMBL4587109 1 -
CHEMBL4475928 1 -
CHEMBL4437092 1 -
CHEMBL4541513 1 -
CHEMBL4468060 1 -
CHEMBL4443066 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL186701 IC50 = 5820.0 nM 5.24
CHEMBL58 MITOXANTRONE IC50 = 40600.0 nM 4.39
CHEMBL4531331 IC50 = 53200.0 nM 4.27
CHEMBL4439843 IC50 = 61900.0 nM 4.21
CHEMBL4559126 IC50 = 66900.0 nM 4.17
CHEMBL4454229 IC50 = 68700.0 nM 4.16
CHEMBL4555875 IC50 = 84000.0 nM 4.08
CHEMBL4560344 IC50 > 100000.0 nM -
CHEMBL188418 IC50 > 100000.0 nM -
CHEMBL4435996 IC50 > 100000.0 nM -
CHEMBL4573546 IC50 > 100000.0 nM -
CHEMBL4455401 IC50 > 100000.0 nM -
CHEMBL4460545 IC50 > 100000.0 nM -
CHEMBL4438086 IC50 > 100000.0 nM -
CHEMBL4591286 IC50 > 100000.0 nM -
CHEMBL4462998 IC50 > 100000.0 nM -
CHEMBL4436800 IC50 > 100000.0 nM -
CHEMBL4552586 IC50 > 100000.0 nM -
CHEMBL4448720 IC50 > 100000.0 nM -
CHEMBL4587109 IC50 > 100000.0 nM -
CHEMBL4475928 IC50 > 100000.0 nM -
CHEMBL4437092 IC50 > 100000.0 nM -
CHEMBL4541513 IC50 > 100000.0 nM -
CHEMBL4468060 IC50 > 100000.0 nM -
CHEMBL4443066 IC50 > 100000.0 nM -