Assay Detail
Binding
CHEMBL4355040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Francisella tularensis IMPDH expressed in Escherichia coli BL21(DE3) deletion in guaB gene using IMP as substrate preincubated for 10 mins followed by substrate addition in presence of NAD by spectrophotometer
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Francisella tularensis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of inosine 5'-monophosphate dehydrogenase as emerging new generation antimicrobial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.72 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207011 | — | — | 1 | 7.89 |
| CHEMBL4213733 | — | — | 1 | 7.81 |
| CHEMBL2348796 | — | — | 1 | 7.66 |
| CHEMBL2348823 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207011 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4213733 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL2348796 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2348823 | — | Ki | = | 30.0 | nM | 7.52 |