Assay Detail
Binding
CHEMBL4355063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human IDO1 expressed in Escherichia coli assessed as reduction in formation of kynurenine using L-tryptophan as substrate measured up to 90 mins by spectrophotometric method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.36 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15192 | LAPACHONE | IC50 | = | 440.0 | nM | 6.36 |