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Assay Detail

CHEMBL4355152

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Functional
Antiproliferative activity against human BGC823 cells assessed as reduction in cell viability after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BGC-823
Confidence 1 — Organism
Curated By Autocuration

Target

BGC-823 (CHEMBL614526)
Type CELL-LINE
Organism Homo sapiens

Publication

Potential Anticancer Agents Characterized from Selected Tropical Plants.
Ren Y, de Blanco EJC, Fuchs JR, Soejarto DD, Burdette JE, Swanson SM, Kinghorn AD.
J Nat Prod (2019) 82 : 657 -679
PubMed 30830783 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 5.69 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4474797 1 6.51
CHEMBL4567687 1 6.07
CHEMBL4483541 1 5.80
CHEMBL4543591 1 5.66
CHEMBL4439079 1 5.50
CHEMBL4452735 1 5.42
CHEMBL4513346 1 5.30
CHEMBL4452643 1 5.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4474797 IC50 = 310.0 nM 6.51
CHEMBL4567687 IC50 = 860.0 nM 6.07
CHEMBL4483541 IC50 = 1600.0 nM 5.80
CHEMBL4543591 IC50 = 2200.0 nM 5.66
CHEMBL4439079 IC50 = 3200.0 nM 5.50
CHEMBL4452735 IC50 = 3800.0 nM 5.42
CHEMBL4513346 IC50 = 5000.0 nM 5.30
CHEMBL4452643 IC50 = 5900.0 nM 5.23