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Assay Detail

CHEMBL4355159

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human Col2 cells assessed as reduction in cell viability
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Col2
Confidence 1 — Organism
Curated By Autocuration

Target

Col2 (CHEMBL614462)
Type CELL-LINE
Organism Homo sapiens

Publication

Potential Anticancer Agents Characterized from Selected Tropical Plants.
Ren Y, de Blanco EJC, Fuchs JR, Soejarto DD, Burdette JE, Swanson SM, Kinghorn AD.
J Nat Prod (2019) 82 : 657 -679
PubMed 30830783 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 6.48 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4562640 1 6.52
CHEMBL4535436 1 6.52
CHEMBL4453872 1 6.40
CHEMBL33256 CHRYSOSPLENOL B 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4562640 IC50 = 300.0 nM 6.52
CHEMBL4535436 IC50 = 300.0 nM 6.52
CHEMBL4453872 IC50 = 400.0 nM 6.40
CHEMBL33256 CHRYSOSPLENOL B IC50 > 10000.0 nM -