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Assay Detail

CHEMBL4355160

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Potential Anticancer Agents Characterized from Selected Tropical Plants.
Ren Y, de Blanco EJC, Fuchs JR, Soejarto DD, Burdette JE, Swanson SM, Kinghorn AD.
J Nat Prod (2019) 82 : 657 -679
PubMed 30830783 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.13 7.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4439599 1 7.37
CHEMBL4450834 1 6.82
CHEMBL4453872 1 6.62
CHEMBL4159192 1 6.58
CHEMBL2205111 1 6.55
CHEMBL4558010 1 6.25
CHEMBL371358 GOIAZENSOLIDE 1 6.25
CHEMBL4436401 1 6.24
CHEMBL4587063 1 6.00
CHEMBL4168591 1 5.92
CHEMBL4476580 1 5.85
CHEMBL4530512 1 5.85
CHEMBL4572647 1 5.72
CHEMBL4160672 1 5.52
CHEMBL4472745 1 5.40
CHEMBL4564201 1 5.18
CHEMBL4476344 1 -
CHEMBL33256 CHRYSOSPLENOL B 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4439599 IC50 = 43.0 nM 7.37
CHEMBL4450834 IC50 = 150.0 nM 6.82
CHEMBL4453872 IC50 = 240.0 nM 6.62
CHEMBL4159192 IC50 = 260.0 nM 6.58
CHEMBL2205111 IC50 = 280.0 nM 6.55
CHEMBL4558010 IC50 = 560.0 nM 6.25
CHEMBL371358 GOIAZENSOLIDE IC50 = 560.0 nM 6.25
CHEMBL4436401 IC50 = 580.0 nM 6.24
CHEMBL4587063 IC50 = 1000.0 nM 6.00
CHEMBL4168591 IC50 = 1200.0 nM 5.92
CHEMBL4476580 IC50 = 1400.0 nM 5.85
CHEMBL4530512 IC50 = 1400.0 nM 5.85
CHEMBL4572647 IC50 = 1900.0 nM 5.72
CHEMBL4160672 IC50 = 3000.0 nM 5.52
CHEMBL4472745 IC50 = 4000.0 nM 5.40
CHEMBL4564201 IC50 = 6600.0 nM 5.18
CHEMBL4476344 IC50 > 10000.0 nM -
CHEMBL33256 CHRYSOSPLENOL B IC50 > 10000.0 nM -