Assay Detail
Binding
CHEMBL4355183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human KLK5 expressed in expressed in Pichia pastoris X-33 cells using Boc-VPR-MCA as susbtrate measured every 60 secs for 10 mins by fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.74 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4466351 | — | — | 1 | 9.47 |
| CHEMBL4550494 | — | — | 1 | 9.14 |
| CHEMBL4575658 | — | — | 1 | 8.62 |
| CHEMBL4456620 | — | — | 1 | 8.43 |
| CHEMBL4513520 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466351 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL4550494 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL4575658 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL4456620 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4513520 | — | Ki | = | 8.9 | nM | 8.05 |