Assay Detail
Binding
CHEMBL4355185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human KLK14 expressed in Spodoptera frugiperda Sf9 cells using Boc-QAR-MCA as susbtrate measured every 60 secs for 10 mins by fluorescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.22 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4466351 | — | — | 1 | 7.75 |
| CHEMBL4456620 | — | — | 1 | 7.10 |
| CHEMBL4575658 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466351 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4456620 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL4575658 | — | Ki | = | 150.0 | nM | 6.82 |