Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4355189

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant KLK14 (unknown origin) expressed in Spodoptera frugiperda Sf9 cells using pNA peptide as susbtrate measured every 10 secs for 300 secs by spectrophotometric analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Kallikrein-14 (CHEMBL2641)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases.
Li CY, de Veer SJ, White AM, Chen X, Harris JM, Swedberg JE, Craik DJ.
J Med Chem (2019) 62 : 3696 -3706
PubMed 30888159 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.60 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4456106 1 7.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4456106 Ki = 25.0 nM 7.60