Assay Detail
Binding
CHEMBL4355299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human liver cathepsin D using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate by FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558459 | HYDRAZOBENZENE | — | 1 | 6.00 |
| CHEMBL4455398 | — | — | 1 | 6.00 |
| CHEMBL4458461 | — | — | 1 | 6.00 |
| CHEMBL3237776 | — | — | 1 | 6.00 |
| CHEMBL121769 | — | — | 1 | 6.00 |
| CHEMBL4530776 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558459 | HYDRAZOBENZENE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4455398 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4458461 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3237776 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL121769 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4530776 | — | IC50 | = | 1000.0 | nM | 6.00 |