Assay Detail
Binding
CHEMBL4355543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human B-RAF V600E mutant using Ser/Thr3 as substrate after 1 hr by FRET-based Z'-Lyte assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.72 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4523007 | — | — | 1 | 7.94 |
| CHEMBL4446003 | — | — | 1 | 7.41 |
| CHEMBL4532800 | — | — | 1 | 7.29 |
| CHEMBL4444385 | — | — | 1 | 7.08 |
| CHEMBL4468296 | — | — | 1 | 6.90 |
| CHEMBL4449013 | — | — | 1 | 6.72 |
| CHEMBL4524151 | — | — | 1 | 6.70 |
| CHEMBL4526537 | — | — | 1 | 6.57 |
| CHEMBL4542865 | — | — | 1 | 6.57 |
| CHEMBL4457930 | — | — | 1 | 6.48 |
| CHEMBL4582776 | — | — | 1 | 6.36 |
| CHEMBL4454493 | — | — | 1 | 6.34 |
| CHEMBL4579609 | — | — | 1 | 6.33 |
| CHEMBL4574656 | — | — | 1 | 6.10 |
| CHEMBL4448690 | — | — | 1 | 6.07 |
| CHEMBL4476053 | — | — | 1 | - |
| CHEMBL4559022 | — | — | 1 | - |
| CHEMBL4457468 | — | — | 1 | - |
| CHEMBL4450810 | — | — | 1 | - |
| CHEMBL4473008 | — | — | 1 | - |
| CHEMBL4452568 | — | — | 1 | - |
| CHEMBL4459658 | — | — | 1 | - |
| CHEMBL4096439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4523007 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4446003 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4532800 | — | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL4444385 | — | IC50 | = | 83.1 | nM | 7.08 |
| CHEMBL4468296 | — | IC50 | = | 125.7 | nM | 6.90 |
| CHEMBL4449013 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4524151 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL4526537 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL4542865 | — | IC50 | = | 272.3 | nM | 6.57 |
| CHEMBL4457930 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL4582776 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL4454493 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL4579609 | — | IC50 | = | 470.3 | nM | 6.33 |
| CHEMBL4574656 | — | IC50 | = | 795.0 | nM | 6.10 |
| CHEMBL4448690 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL4476053 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4559022 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4457468 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4450810 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4473008 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4452568 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4459658 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4096439 | — | IC50 | > | 1000.0 | nM | - |