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Assay Detail

CHEMBL4355632

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells incubated for 48 hrs by sulforhodamine B staining based ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review.
Sangshetti J, Pathan SK, Patil R, Akber Ansari S, Chhajed S, Arote R, Shinde DB.
Bioorg Med Chem (2019) 27 : 3979 -3997
PubMed 31401008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 8.00 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4462284 1 8.00
CHEMBL4471588 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4462284 IC50 = 10.0 nM 8.00
CHEMBL4471588 IC50 = 10.0 nM 8.00